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KMID : 0358420080510111288
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 11 p.1288 ~ p.1294
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The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas
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Park Chang-Min
Han Song-Yee
Kim In-Sun
Kim Hyun-Chul
Kang Jae-Seong
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Abstract
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Objective: The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters.
Methods: One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity.
Results: Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients.
Conclusions: Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
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KEYWORD
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Ki-67 antigen, Immunohistochemistry, Ovary, Carcinoma
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